Mechanobiology
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Mechanobiology Syllabus — Unit-wise Content
The official GTU curriculum for Mechanobiology (subject code 3170417) as prescribed for Biotech · Semester 7 divides the course into 3 units, covering 29 listed topics. The unit-wise breakdown below is read from the GTU syllabus document for this subject code, so you can check what the course actually covers before deciding which papers to attempt.
Download the official syllabus PDF (3170417)Unit 1 UNIT I
- Introduction to Mechanobiology What is a cell
- the plasma membrane
- transmembrane proteins
- cell signalling via juxtacrine signals
- Extracellular matrix
- Cell- ECM cross talk
- Mechanosensitive ion channels
- stress fibres and focal adhesions
Unit 2 UNIT II
- Key players of mechanosensing Contributors to cellular mechanosensing
- passive and active mechano sensing
- Role of the ECM in mechanobiology
- Signaling pathways- Outside:In and Inside:Outmechanotrasnduction
- The cytoskeleton (CSK)
- Focal Adhesion assembly (paxillin
- VASP, FAK, Tensin)
Unit 3 UNIT III
- Techniques for studying mechanical properties of cells and ECM Rheology studies
- AFM and AFM probe designs
- Moving forward from 2D to 3D using hydrogels
- Traction Force Microscopy
- Trypsin Deadhesion& Laser Ablation
- UNIT IV: Studying Mechanobiology of Cytoskeleton
- ECM andFocal adhesion
- Rheology studies with collagen an ECM protein
- Protein Unfolding as a means for mechano transduction- study using AFM, Understanding actin networks
- 14 Subject Code: 3170417 w.e.f
- AY 2018-19 Adhesion independent cell migration. 6
- UNIT V: Mechanobiology of diseases Mechanobiology of Atheroscleorsis
- Mechanobiology of cancer
- Mechanobiology of Muscular dystrophy
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