Genomics and Proteomics
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Genomics and Proteomics Syllabus — Unit-wise Content
The official GTU curriculum for Genomics and Proteomics (subject code 3170416) as prescribed for Biotech · Semester 7 divides the course into 3 units, covering 59 listed topics. The unit-wise breakdown below is read from the GTU syllabus document for this subject code, so you can check what the course actually covers before deciding which papers to attempt.
Download the official syllabus PDF (3170416)Unit 1 Genomics and methods in genomics
- Organization and structure of genomes in prokaryotes
- eukaryotes, and organelles (chloroplast
- Genome mapping methods (genetic and physical)
- SNP analyses
- Fluorescence in-situ Hybridization (FISH) techniques
- Advances in gene finding and functional prediction
- Chain termination and chemical degradation sequencing methods
- Genome-wide association (GWA) analysis
- Comparative Genomic Hybridization (CGH)
- Massively parallel Signature Sequencing (MPSS)
- Whole genome shot-gun sequencing and its applications
- Introduction of Next Generation Sequencing (NGS)
Unit 2 Transcriptomics and methods in transcriptomics
- Basic principles and design
- cDNA and oligonucleotide arrays
- DNA microarray
- Instrumentation and structure
- Designing a microarray experiment - The basic steps
- Types of microarray - expression arrays
- protein arrays
- Comparative Genomic Hybridization (CGH) arrays
- 20 Subject Code: 3170416 w.e.f
- AY 2018-19 Resequencing arrays
- Different platforms (Affymetrix
- Agilent etc.)
- Data Processing and Normalization - Algorithms of data processing and Normalization
- Tools used to normalize
- Microarray databases – NCBI
- GEO (Gene Expression Omnibus)
- ArrayExpres (EBI)
- Functional Analysis: Differential gene expression
- Gene Ontology functional enrichment tools
- Pathway analysis (KEGG Database)
- Applications of Microarray technology
- case studies
Unit 3 Proteomics and methods in proteomics
- Overview of protein structure-primary
- tertiary and quarternary structure
- Relationship between protein structure and function
- Outline of a typical proteomics experiment
- Identification and analysis of proteins by 2D analysis
- Spot visualization and picking
- Tryptic digestion of protein and peptide fingerprinting
- Mass spectrometry : ion source (MALDI
- spray sources)
- analyzer (ToF
- quadruple ion trap) and detector
- Post translational Modifications: Quantitative proteomics
- clinical proteomics and disease biomarkers
- mass spectral tissue imaging and profiling
- Proteinprotein interactions: Surfaceomes and Secretomes
- Solid phase ELISA
- pull-down assays (using GST-tagged protein) tandem affinity purification
- far western analysis
- by surface plasmon resonance technique
- Yeast two hybrid system
- Phage display
- Protein interaction maps
- Protein arrays-definition
- applications- diagnostics
- expression profiling
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