Downstream Processes
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Downstream Processes Syllabus — Unit-wise Content
The official GTU curriculum for Downstream Processes (subject code 3170411) as prescribed for Biotech · Semester 7 divides the course into 6 units, covering 51 listed topics. The unit-wise breakdown below is read from the GTU syllabus document for this subject code, so you can check what the course actually covers before deciding which papers to attempt.
Download the official syllabus PDF (3170411)Unit 1 INTRODUCTION TO BIOPRODUCTS AND BIOSEPERATIONS Broad Classification of Bioproducts, Small Biomolecules, Macromolecule
- Nucleic Acid and Oligonucleotides
- Particulate Products
- Introduction to Bioseperations
Unit 2 Disruption of microbial cells
- Composition and structure of cell walls (Bacteria
- yeast and other fungi)
- Analysis of Disruption (direct and indirect measurement)
- Laboratory scale disruption techniques (mechanical and non mechanical)
- large scale disruption techniques (High speed Ball Mills
- High pressure homogenizers and others) 4 Subject Code: 3170411 w.e.f
Unit 3 PHYSICAL METHODS OF SEPERATION
- Filtration Principles
- Filter Media and Equipment
- Membrane Fouling
- Scale up and Design of Filtration Systems Sedimentation Principle
- Methods and coefficients
- Production Centrifuges
- Flocculation and Sedimentation
- Sedimentation at Low Accelerations
- Centrifugal Elutriation
Unit 4 ISOLATION OF PRODUCTS
- Liquid-Liquid Extraction: Introduction
- biochemical and technical aspects
- Solvent selection
- Extraction equipment selection
- Process Considerations
- Analytical applications Adsorption: Chemistry
- Batch adsorption
- Adsorption in continuous stirred tank
- adsorption in fixed beds Precipitation:Principle
- Precipitate formation phenomenon
- Precipitation with a non solvent
- precipitation with salts
- precipitation with temperature
- Design of precipitationsystems
Unit 5 PRODUCT RESOLUTION
- 1) Molecular sieve chromatography (Introduction
- operations) 2) Ion Exchange chromatography (Introduction
- operations) 3) Affinity Chromatography ( Introduction
- spacer arms
- coupling procedures
- theoretical modeling
- applications) 4) Hydrophobic chromatography (Introduction
- structure and synthesis of 12 Subject Code: 3170411 w.e.f
- AY 2018-19 hydrophobic matrices
- theoretical aspects
- applications and resolving power) 5) High Performance Liquid Chromatography (Introduction
- theory and practice
- gradient and scale up)
Unit 6 PRODUCT FINISHING
- Crystallization: Principles
- Batch Crystallizers
- Process Crystallization of Proteins
- Crystallizer Scale up and Design Drying : Drying Principles
- Dryer Description and Operation
- Scale up and Design of Drying Systems
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