Unit 1 INTRODUCTION

2 lecture hours

• Definition Of Biomaterials
• Mechanical Properties
• Surface Chemistry Of Materials
• Surface Modification
• Tissue Reaction
• Wound Kinetics, And Bio Compatibility
• Physical And Mechanical Properties Of Biomaterials

Unit 2 MATERIALS IN MEDICAL DEVICES

6 lecture hours

• Polymers And Composites And Biological Materials
• Material Preparation
• Chemical Composition
• Uses In Medicine And Biosciences And Failure Mechanisms

Unit 3 STERLIZATION OF BIOMATERIALS

4 lecture hours

• Sterilization Techniques: – Process And Mechanism Of Action Of Steam Sterilization
• Electron Beam Sterilization
• Ethylene Oxide
• Chlorine Dioxide And Plasma Gas, Sterilization

Unit 4 TESTING OF MATERIALS

6 lecture hours

• Testing With Tissue Culture – In Vitro And In Vivo Assessment Of Biocompatibility
• Testing With Soft
• Tissues And Testing At Non Thrombogenic Surface – Blood Compatibility And Thromobogenicity
• Biomaterials Degradation In The Biological Environment

Unit 5 Biocompatibility

• Biocompatibility And Tissue Response: Biocompatibility Hierarchy- Ramifications In Implant Design And Applications
• Host Reactions To

Unit 6 Particulate Biomaterials

6 lecture hours

• Type Of Reactions
• Particle Surface
• Cell Surface And Signaling Mechanism
• Chemical Mediators
• Protein And Cell Interactions With Biomaterials
• Protein Conformations
• The Conformation Stabilization Forces. 6 Biodegradability Biodegradability
• Resorption And Stability: Biodegradable Suture Materials
• Factors Affecting Biodegradation Phenomena
• Intrinsic Factors –Substituent Effect
• Morphological Effect
• Annealing Effect
• Extrinsic Factors – Effect Of Media Ph, Effect Of Electrolytes
• Effect Of External Stress Applied

Unit 7 Applications Of Biomaterials ,Nanomaterials And Nanotechnology

6 lecture hours

• Orthopedics Applications: Upper Extremities
• Lower Extremities And Spine
• Dental Implantation
• Tissue Engineering Scaffolds
• Bone Tissue Engineering
• Plastic Surgery
• Advance Nanomaterial Applications
• Bio MEMS
• Magnetic Particles For Biomedical Applications

Unit 8 Special Considerations For Implants, Devices And Biomaterials

6 lecture hours

• Regulatory Compliance 8.2
• Commercialization: What It Takes To Get A Product To The Market 8.3
• Legal Aspects Of Biomaterials
• Clinical Trials And Case Studies In Regulation