Biochemical Engineering-II
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Follow on Instagram for UpdatesBiochemical Engineering-II Syllabus — Unit-wise Content
The official GTU curriculum for Biochemical Engineering-II (subject code 2180408) as prescribed for Biotech · Semester 8 divides the course into 5 units, covering 59 listed topics. The unit-wise breakdown below is read from the GTU syllabus document for this subject code, so you can check what the course actually covers before deciding which papers to attempt.
Download the official syllabus PDF (2180408)Unit 1 UNIT I
- Media Optimization and Monitoring of bioprocesses: Plackett – Burman Design
- Response surface optimization
- simplex search method
- Methods of on-line and off-line bio-mass estimation.Flow injection analysis
Unit 2 UNIT II
- Simulation softwares: Modelling and simulation of bioprocesses: Study of structured models for analysis of various bioprocesses– compartmental models
- models of cellular energetics and metabolism
- single cell models
- plasmid replication and plasmid stability model
- Dynamic simulation of batch
- fed batch
- steady and transient culture metabolism
- Model simulation using MATLAB- SIMULINK software packages
- Modelling of Recombinant bacterial cultures
- Bioreactor strategies for maximising product formation
Unit 3 UNIT III
- Biosensor Technology: Principles
Unit 4 Unit IV
- Downstream Processing: Role of downstream processing in biotechnological processes
- Disruption of microbial cells: Composition and structure of cell walls (Bacteria
- yeast and other fungi)
- Analysis of Disruption (direct and indirect measurement)
- Laboratory scale disruption techniques (mechanical and non mechanical)
- large scale disruption techniques (High speed Ball Mills
- High pressure homogenizers and others) Flocculation: Electric Double layer
- Forces between Particles and flocculation by electrolytes
- The Schulze Hardy Rule
- Flocculation rate
- Sedimentation: Principle
- methods and coefficients
- sedimentation at low accelerations
- Centrifugation: Introduction
- Fluid and particle dynamics (Stoke’s law, Settling in centrifugal field
- Hindered settling)
- Centrifuge configurations (Tubular Bowl centrifuge
- Chamber centrifuges
- Decanter Centrifuges
- Disc- stack centrifuge)
- Scale up (Tubular Bowl centrifuge
- Types of separator (Solid Bowl Machines and Solids discharging Disc separators)
- Methods for selection of centrifuge and applications Filtration: Introduction
- filter aids
- Tangential flow filtration
- Hollow fiber membranes
- Ultra filtration in biotechnology
- Liquid-Liquid Extraction: Introduction
- biochemical and technical aspects
- Solvent selection
- Extraction equipment selection
- Process Considerations
- Analytical applications Adsorption: Chemistry
- Batch adsorption
- Adsorption in continuous stirred tank
- adsorption in fixed beds Precipitation: Principle
- Precipitate formation phenomenon
Unit 5 Unit V
- Economics of downstream processing in Biotechnology
- cost-cutting strategies
- characteristics of biological mixtures
- process design criteria for various classes of bio products (high volume
- low value product and low volume
- high value product)
- physico- chemical basis of bio separation processes
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