Molecular Biology and Genetics
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Molecular Biology and Genetics Syllabus — Unit-wise Content
The official GTU curriculum for Molecular Biology and Genetics (subject code 3140409) as prescribed for Biotech · Semester 4 divides the course into 6 units, covering 52 listed topics. The unit-wise breakdown below is read from the GTU syllabus document for this subject code, so you can check what the course actually covers before deciding which papers to attempt.
Download the official syllabus PDF (3140409)Unit 1 Unit I Basics of Genetics
- History and development of early genetics
- Mendel's experiments and laws of heredity
- various types of crosses
- Mendelian Inheritance and Probability
- Nature and properties of genetic material
- linkage and crossing over
- cytoplasmic inheritance and its significance
- sexlinked inheritance and chromosomal disorders
Unit 2 Unit II Concept of Genetic material and Gene
- Properties of Genetic material
- Evidence of DNA as genetic material in akaryotes
- prokaryotes and eukaryotes
- Denaturation and renaturation of DNA, Concept of gene
- recon and muton
- One gene one protein hypothesis
- prokaryotic gene structure
- eukaryotic gene structure
Unit 3 Unit III DNA Replication
- Semi-conservative and Dispersive model of DNA replication
- Uni- and bi- directional replication
- Enzymology of prokaryotic and eukaryotic DNA replication
- Role of primer in DNA replication
- Concept of Primosome
- Replisome and replicons
- Mechanism of DNA replication in prokaryotes and eukaryotes
- Subject Code: 3140409 postreplicational modification
Unit 4 Unit IV Transcription
- Basic features of transcription
- Requirement of transcription
- Enzyme RNA polymerase
- Concept of Auxillary proteins
- silencer and enhancer
- Mechanism of Transcription in prokaryotes and eukaryotes
- Monocistronic and Polycistronic mRNA
- Post 11 hrs 25% transcriptional modification of mRNA
- tRNA and rRNA
- Splicing mechanism of RNA
- Regulation of transcription
Unit 5 Unit V Genetic Code and Translation
- The discovery of genetic code
- concept of genetic code
- types and characteristics of genetic code
- Redundancy of genetic codon
- Wobble and adaptor hypothesis
- Overview of protein synthesis
- mechanism of translation in prokaryotes and eukaryotes
- post translational modification
Unit 6 DNA Mutation and Repair
- General properties and terminologies of mutation
- Molecular basis of mutation
- Types of mutation
- Detection and selection of mutants
- Reverse mutation and suppression of mutation Mismatch repair
- Excision repair
- Mismatch repair
- Post replicational repair
- Recombinational repair and SOS system
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