Modelling & Simulation of Physiological systems
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Modelling & Simulation of Physiological systems Syllabus — Unit-wise Content
The official GTU curriculum for Modelling & Simulation of Physiological systems (subject code 2150305) as prescribed for Biomed · Semester 5 divides the course into 7 units, covering 36 listed topics. The unit-wise breakdown below is read from the GTU syllabus document for this subject code, so you can check what the course actually covers before deciding which papers to attempt.
Download the official syllabus PDF (2150305)Unit 1 Basic Concepts Of Physiological System
- Introduction to physiological system and mathematical modelling of physiological system
- classification of model – grey box & black box, parametric & non parametric
- lumped & distributed models
- linear & non-linear
- characteristics of models
- Purpose of physiological modelling and signal analysis
- linearization of nonlinear models
- Engineering system and physiological system
- System variables & properties- Resistance
- Compliance & their analogy
Unit 2 Linear Model
- respiratory mechanics & muscle mechanics
- Voltage clamp experiment - Hodgkin and Huxley’s model of action potential
- model for strength-duration curve
- model of the whole neuron
Unit 3 Cardio-Pulmonary Modelling
- Cardiovascular system and pulmonary mechanics modelling and simulation
- Model of Cardiovascular Variability
- Model of Circadian Rhythms. 7 12%
Unit 4 Time-Domain Analysis of Linear Control Systems
- Time domain analysis – Introduction to first order and second order model -Respiratory mechanics – open loop and closed loop model of lung mechanics – First order model – impulse and step response – Second order model – Impulse response – undamped
- under damped
- critically damped, and over damped behaviour – Method of obtaining step response from impulse response – Transient response descriptors – Model of neuromuscular reflex motion – Transient response analysis using MATLAB
Unit 5 Steady State Analysis Of Physiological System
- Close loop verses open loop system
- Steady state analysis of Muscle stretch reflex using SIMULINK
- Regulation of Cardiac output
- Regulation of Glucose – Insulin regulation
- Chemical regulation of Ventilation
- Case study: Stability Analysis of the Pupillary Light Reflex
- Model of Cheyne-Stokes Breathing
Unit 6 Frequency Domain Analysis
- Frequency response analysis of linearized lung mechanics
- circulatory control system
- glucose insulin regulation by MATLAB tool 5 25%
Unit 7 Eye Movement Model
- Types of Eye movement
- Eye movement system and Wetheimer’s saccade eye model
- Robinson’s Model
- Oculomotor muscle model
- Linear Reciprocal Innervations Oculomotor Model
- TOTAL HOURS 45 100%
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